Medical News Today: What are the benefits of lion’s mane mushrooms?

Abdulla, M. A., Fard, A. A., Sabaratnam, V., Wong, K. H., Kuppusamy, U. R., Abdullah, N., & Ismail, S. (2011). Potential activity of aqueous extract of culinary-medicinal lion’s mane mushroom, Hericium erinaceus (Bull.: Fr.) Pers. (Aphyllophoromycetideae) in accelerating wound healing in rats [Abstract]. International Journal of Medicinal Mushrooms, 13(1), 33–39. Retrieved from https://www.ncbi.nlm.nih.gov/pubmed/22135902

Abdullah, N., Ismail, S. M., Aminudin, N., Shuib, A. S., & Lau, B. F. (2012). Evaluation of selected culinary-medicinal mushrooms for antioxidant and ACE inhibitory activities. Evidence-Based Complementary and Alternative Medicine, 2012. Retrieved from https://www.hindawi.com/journals/ecam/2012/464238/

Brandalise, F., Cesaroni, V., Gregori, A., Repetti, M., Romano, C., Orrù, G., … Rossi, P. (2017, January 1). Dietary supplementation of Hericium erinaceus increases mossy fiber-CA3 hippocampal neurotransmission and recognition memory in wild-type mice. Evidence-Based Complementary and Alternative Medicine, 2017. Retrieved from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5237458/

Chiu, C.-H., Chyau, C.-C., Chen, C.-C., Lee, L.-Y., Chen, W.-P., Liu, J.-L., … Mong, M.-C. (2018, February). Erinacine A-enriched Hericium erinaceus mycelium produces antidepressant-like effects through modulating BDNF/PI3K/Akt/GSK-3β signaling in mice. International Journal of Molecular Sciences, 19(2), 341. Retrieved from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5855563/

Choi, W.-S., Kim, Y.-S., Park, B.-S., Kim, J.-E., & Lee, S.-E. (2013, June 30). Hypolipidaemic effect of Hericium erinaceum grown in Artemisia capillaris on obese rats. Mycobiology, 41(2), 94–99. Retrieved from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3714447/

Diling, C., Chaoqun, Z., Jian, Y., Jian, L., Jiyan, S., Yizhen, X., & Guoxiao, L. (2017, June 12). Immunomodulatory activities of a fungal protein extracted from Hericium erinaceus through regulating the gut microbiota. Frontiers in Immunology, 8, 666. Retrieved from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5492111/

Kim, S. P., Kang, M. Y., Choi, Y. H., Kim, J. H., Nam, S. H., & Friedman, M. (2011, June 8). Mechanism of Hericium erinaceus (Yamabushitake) mushroom-induced apoptosis of U937 human monocytic leukemia cells [Abstract]. Food & Function, 2(6), 348–356. Retrieved from https://www.ncbi.nlm.nih.gov/pubmed/21779573

Lakshmanan, H., Raman, J., David, P., Wong, K. H., Naidu, M., & Sabaratnam, V. (2016, December 24). Haematological, biochemical and histopathological aspects of Hericium erinaceus ingestion in a rodent model: A sub-chronic toxicological assessment [Abstract]. Journal of Ethnopharmacology, 194, 1051–1059. Retrieved from https://www.ncbi.nlm.nih.gov/pubmed/27816657

Li, G., Yu, K., Li, F., Xu, K., Li, J., He, S., … Tan, G. (2014, April 28). Anticancer potential of Hericium erinaceus extracts against human gastrointestinal cancers [Abstract]. Journal of Ethnopharmacology, 153(2), 521–530. Retrieved from https://www.ncbi.nlm.nih.gov/pubmed/24631140

Liang. B., Guo, Z., Xie, F., & Zhai, A. (2013, October 3). Antihyperglycemic and antihyperlipidemic activities of aqueous extract of Hericium erinaceus in experimental diabetic rats. BMC Complementary and Alternative Medicine, 2013(13), 253. Retrieved from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3852124/#__ffn_sectitle

Liu, J. H., Li, L., Shang, X. D., Zhang, J. L., & Tan, Q. (2016, May 13). Anti-Helicobacter pylori activity of bioactive components isolated from Hericium erinaceus [Abstract]. Journal of Ethnopharmacology, 183, 54–58. Retrieved from https://www.ncbi.nlm.nih.gov/pubmed/26364939

Mori, K., Inatomi, S., Ouchi, K., Azumi, Y., & Tuchida, T. (2009, March). Improving effects of the mushroom Yamabushitake (Hericium erinaceus) on mild cognitive impairment: A double‐blind placebo‐controlled clinical trial [Abstract]. Phytotherapy Research, 23(3), 367–372. Retrieved from https://www.ncbi.nlm.nih.gov/pubmed/18844328

Nagano, M., Shimizu, K., Kondo, R., Hayashi, C., Sato, D., Kitagawa, K., & Ohnuki, K. (2010, August). Reduction of depression and anxiety by 4 weeks Hericium erinaceus intake. Biomedical Research, 31(4), 231–237. Retrieved from https://www.jstage.jst.go.jp/article/biomedres/31/4/31_4_231/_pdf/-char/en

Samberkar, S., Gandhi, S., Naidu, M., Wong, K. H., Raman, J., & Sabaratnam, V. (2015). Lion’s mane, Hericium erinaceus and tiger milk, Lignosus rhinocerotis (higher basidiomycetes) medicinal mushrooms stimulate neurite outgrowth in dissociated cells of brain, spinal cord, and retina: An in vitro study [Abstract]. International Journal of Medicinal Mushrooms, 17(11), 1047–1054. Retrieved from https://www.ncbi.nlm.nih.gov/pubmed/26853959

Sheng, X., Yan, J., Meng, Y., Kang, Y., Han, Z., Tai, G., … Cheng, H. (2017, March 22). Immunomodulatory effects of Hericium erinaceus derived polysaccharides are mediated by intestinal immunology [Abstract]. Food & Function, 8(3), 1020–1027. Retrieved from https://www.ncbi.nlm.nih.gov/pubmed/28266682

Wang, M., Konishi, T., Gao, Y., Xu, D., & Gao, Q. (2015). Anti-gastric ulcer activity of polysaccharide fraction isolated from mycelium culture of lion’s mane medicinal mushroom, Hericium erinaceus (higher basidiomycetes) [Abstract]. International Journal of Medicinal Mushrooms, 17(11), 1055–1060. Retrieved from https://www.ncbi.nlm.nih.gov/pubmed/26853960

Wong, K.-H., Naidu, M., David, P., Abdulla, M. A., Abdullah, N., Kuppusamy, U. R., & Sabaratnam, V. (2011, August 11). Peripheral nerve regeneration following crush injury to rat peroneal nerve by aqueous extract of medicinal mushroom Hericium erinaceus (Bull.: Fr) Pers. (Aphyllophoromycetideae). Evidence-Based Complementary and Alternative Medicine, 2011. Retrieved from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3176599/

Yao, W., Zhang, J. C., Dong, C., Zhuang, C., Hirota, S., Inanaga, K., & Hashimoto, K. (2015, September). Effects of amycenone on serum levels of tumor necrosis factor-α, interleukin-10, and depression-like behavior in mice after lipopolysaccharide administration [Abstract]. Pharmacology, Biochemistry, and Behavior, 136, 7–12. Retrieved from https://www.ncbi.nlm.nih.gov/pubmed/26150007

Yi, Z., Shao-long, Y., Ai-hong, W., Zhi-chun, S., Ya-fen, Z., Ye-ting, X., & Yu-ling, H. (2015, April 16). Protective effect of ethanol extracts of Hericium erinaceus on alloxan-induced diabetic neuropathic pain in rats. Evidence-based Complementary and Alternative Medicine, 2015. Retrieved from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4415746/

Zhang, J., An, S., Hu, W., Teng, M., Wang, X., Qu, Y., … Wang, D. (2016, November 1). The neuroprotective properties of Hericium erinaceus in glutamate-damaged differentiated PC12 cells and an Alzheimer’s disease mouse model. International Journal of Molecular Sciences, 17(11), 1810. Retrieved from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5133811/